Lipid Nanoparticles

Lipid Nanoparticle Formulation Solutions

Lipid Nanoparticles

Lipid Nanoparticles (LNPs) are nanoscale lipid-based carriers—including liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs). They can encapsulate nucleic acids, proteins, peptides, and other bioactive molecules, enabling efficient, controlled delivery with enhanced stability and biocompatibility.

Whether you are developing next-generation therapeutics, advanced cosmetic formulations, or nutritional products, LNPs provide reliable, scalable, and reproducible delivery solutions, making them an essential tool in modern nanomedicine and formulation research.

Applications of LNPs

Pharmaceutical & Gene Delivery:

mRNA vaccines, siRNA therapeutics, protein and peptide delivery, and other advanced therapies.

Cosmetic & Skincare:

Anti-aging serums, moisturizers, sunscreens, and masks with improved skin penetration and controlled release.

Nutritional Supplements:

Lipid-soluble vitamins and bioactive compounds with enhanced bioavailability.

Research & Laboratory:

Model drug carriers for formulation studies, particle size optimization, and in vitro delivery experiments.

Formulating LNPs consistently—while maintaining particle size, stability, and bioactivity—can be challenging at both lab and production scale. Genizer’s equipment solutions simplify this process, ensuring reproducible results across all applications.

Genizer Solutions for LNP Formulation

Genizer offers a comprehensive portfolio of equipment for lipid nanoparticle (LNP) and liposome formulation and resizing, supporting workflows from early-stage research to industrial manufacturing.

Microfluidic NanoMixer forNanoparticle Formulations

Microfluidic NanoMixer

NanoMixer is a precision microfluidic mixing platform designed for laboratory-scale formulation of mRNA, DNA, and siRNA delivery systems. It enables controlled and reproducible mixing using gastight syringes with flexible multi-component configurations.

The system is electrically driven and designed for sterile, low dead-volume operation, ensuring consistent and uniform formulation performance for sensitive biopharmaceutical applications.

Liposome Extruders for Lipid Nanoparticles, Liposomes

Liposome Extruders

Liposome extruders are mainly used for liposome formulation and achieving uniform particle size distribution. They are widely applied in the preparation of nanoscale liposomes, exosomes, and artificial cell membrane systems.

By forcing vesicles through polycarbonate membranes under pressure, liposome extruders enable precise control of particle size, similar to passing material through a fine strainer.

This process is scalable, supporting a seamless transition from milliliter-scale laboratory development to liter-scale and industrial production while maintaining consistent particle size and formulation conditions.

Liposome extruders are available in manual, gas-driven, and electrically powered pump systems, offering flexible configurations across different scales.

High Pressure Homogenizers for Lipid Nanoparticle Formulations

High-Pressure Homogenizers

High-pressure homogenizers operate at pressures of up to 60,000 psi, forcing formulations through narrow channels where intense shear, turbulence, and cavitation are generated, enabling controlled particle size reduction.

During this process, high-energy mechanical forces promote the formation of uniform nanoscale dispersions with improved consistency and reproducibility.

Genizer high-pressure homogenizers are designed for scalable lipid nanoparticle (LNP) processing, supporting workflows from laboratory research and process development to pilot-scale optimization and industrial manufacturing. These systems are suitable for GMP-compliant production and enable precise particle size control, ensuring reliable batch-to-batch performance.

To help you select the most suitable LNP technology for your application, read our guide on Liposome Processing: High-Pressure Homogenizer or Liposome Extruder?.

Integrated Process Support from Lab to Manufacturing

Genizer technologies are designed to support the full development lifecycle of lipid-based formulations. Whether working at research scale or preparing for industrial production, our platforms enable controlled, reproducible, and scalable nanoparticle processing.

Contact Genizer for LNP Process Equipment

Need help scaling your LNP formulation or selecting the right technology? Contact Genizer to discuss your application or request a demo.

Email: info@genizer.com

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